Causes of Dark Circles by Type: The Biology of Vascular Permeability and Pigmentation

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Chapter 1: The Frustrating Reality of Dark Circles (And Why You Are Not Alone)

If you are reading this, chances are you have stood in front of a mirror on a busy morning, staring at the persistent shadows under your eyes, and felt a profound sense of despair. You are doing everything "right"—drinking water, trying to get a full eight hours of sleep, and investing in high-end eye creams. Yet, those stubborn, exhausting dark circles remain, making you look perpetually tired, stressed, or older than you actually are. If your skin state feels hopeless right now, please know that you are absolutely not alone. For women in their twenties, thirties, and forties balancing demanding careers, social lives, and environmental stressors, periorbital hyperpigmentation is one of the most universally shared, yet deeply misunderstood, cosmetic frustrations globally.

We often blame ourselves, attributing these shadows to late nights or too much screen time. But the truth is far more complex. While lifestyle factors play a role, treating infraorbital darkening solely as a consequence of insufficient sleep is a fundamental oversimplification.1 In fact, clinical studies reveal that sleep deprivation is often not directly correlated with the severity of dark circles in the way we assume; instead, the condition is primarily driven by intricate physiological, genetic, and structural factors.1 Research indicates that the average age of onset is surprisingly early—around 24 years of age—and those who develop them earlier often experience higher severity scores as they age.1

To truly resolve this condition, we need to shift our approach from emotional frustration and temporary concealers to objective, targeted science. The Korean beauty (K-Beauty) industry has revolutionized global skincare precisely because of this philosophy: rather than merely masking a symptom, we must diagnose and treat the underlying biological root cause. Periorbital hyperpigmentation (POH) is not a single, uniform issue. It is a highly variable condition driven by three distinct biological mechanisms: hyperpigmentation (the overproduction of melanin), vascular permeability (leaky capillaries and blood stasis), and structural shadowing (thinning skin and volume loss).2

By understanding the unique biology of your specific type of dark circle, we can transition from a cycle of trial and error to a highly effective, clinical-grade skincare regimen. It is time to demystify the science behind your skin and equip you with the exact knowledge needed to reclaim a radiant, well-rested appearance.

Chapter 2: The Biology of Vascular Permeability: When Your Skin Leaks

To understand why your under-eye area might appear bruised with a distinct bluish, pink, or purplish hue, we must transition into the microscopic histology of the periorbital tissue. This specific discoloration, known as vascular dark circles, is not caused by an excess of skin pigment. Instead, it is the visual manifestation of complex circulatory dynamics and structural vulnerabilities occurring just beneath the epidermal barrier.3

The infraorbital region is anatomically predisposed to fluid accumulation (edema) and blood stasis, which is the sluggish pooling or slowing of blood flow.3 A defining biological mechanism behind this subtype of dark circle is increased vascular permeability. As a result of chronic inflammation, environmental stress, and age-related degradation, the localized capillary network becomes fragile and hyper-permeable.6 Advanced diagnostic tools, such as videocapillaroscopy, have demonstrated that the under-eye regions in affected individuals possess capillary networks that are significantly more dilated, thicker, and higher in number compared to unaffected facial skin.3

When these microscopic vessels dilate and their walls weaken, red blood cells escape the vascular network and leak into the surrounding cutaneous and subcutaneous tissues—a physiological process known as extravasation.5 Once these red blood cells are trapped outside the capillaries, the body's immune system begins to break them down, releasing a protein called hemoglobin.6

As hemoglobin degrades, it undergoes a biochemical transformation, leaving behind localized deposits of breakdown products such as biliverdin and, most notably, hemosiderin.6 Hemosiderin is an iron-storage protein complex. When it accumulates in the tissue, it causes "hemosiderin staining," which visually presents as a rusty, brownish-yellow, or dark purplish shadow that looks strikingly similar to a permanent bruise.7 Because hemosiderin contains iron, the discoloration is fundamentally different from melanin. This explains why standard skin-brightening creams completely fail on vascular dark circles; hemosiderin staining operates through blood coagulation and cellular degradation pathways, requiring entirely different, specialized therapeutic interventions.9

Furthermore, lifestyle factors serve as immediate catalysts for vascular dark circles. Dehydration, excessive alcohol consumption, and physical exhaustion reduce overall cardiovascular efficiency, causing peripheral blood vessels to dilate and become visibly prominent beneath the skin.11 During sleep, the lack of an active lymphatic drainage mechanism allows interstitial fluid to pool around the eyes. This nocturnal fluid retention results in morning puffiness that physically stretches the already fragile vascular walls, exacerbating permeability and subsequent hemoglobin leakage.2

Vascular Factor	Biological Mechanism	Visual Manifestation
Capillary Dilation	Enlargement of local blood vessels due to poor circulation, histamine release, or inflammation.	Bluish, pinkish, or red undertones visibly shining through the skin.
Blood Stasis	Sluggish blood flow leading to localized pooling of deoxygenated blood in the infraorbital area.	Deeper blue or purplish shadows, often looking worse in the morning or after exhaustion.3
Erythrocyte Extravasation	Leakage of red blood cells into surrounding tissue due to weakened, hyper-permeable capillary walls.6	An initial bruising appearance that transitions into chronic discoloration.
Hemosiderin Staining	Accumulation of iron-rich proteins from the degradation of escaped red blood cells.7	Stubborn rusty, brownish-yellow, or dark purple pigment that mimics a permanent shadow.7

Chapter 3: The Biology of Pigmentation: Melanin Overdrive and Structural Shadows

While vascular issues stem from the blood, pigmented dark circles are driven by the overproduction and uneven distribution of melanin, the biological pigment responsible for skin color. Clinically referred to as periorbital melanosis, this condition typically presents as bilateral, homogenous brown or dark brown macules curving along the periocular region.5 Hyperspectral imaging and multispectral analysis confirm that for many individuals, a high melanin index is the dominant biological correlate for the severity of their dark circles.1

Melanin-driven dark circles generally originate from two primary pathways: genetic predisposition and post-inflammatory hyperpigmentation (PIH).5

Genetics exert a profound influence on the baseline distribution of melanocytes (melanin-producing cells) in the periorbital area. Family history is widely recognized as the single most significant risk factor for periorbital dark circles.1 In many familial cases, individuals exhibit dermal melanocytosis—a condition where melanocytes are abnormally located deep within the dermal layer rather than the superficial epidermis, casting a distinct grey or blue-grey shadow that is notoriously difficult to treat.5 Additionally, natural physiological transitions in skin tone, known as pigmentary demarcation lines, frequently extend into the infraorbital region, creating intrinsically darker semi-circles.5

The second, and highly common, pathway is Post-Inflammatory Hyperpigmentation (PIH). The periorbital skin is incredibly susceptible to localized inflammation triggered by environmental allergens, atopic dermatitis (eczema), and contact dermatitis from cosmetics.5 Clinical studies have established a significant correlation between asthma (often an indicator of systemic atopy) and high dark circle severity scores.1 When the skin becomes inflamed, or when an individual engages in chronic eye rubbing due to itching, the mechanical trauma and chemical inflammatory mediators send the local melanocytes into overdrive.12

Upon stimulation, the enzyme tyrosinase acts as a catalyst, converting the amino acid tyrosine into dopa, and subsequently into excess melanin.5 This melanin is then packaged into melanosomes and transferred to the surrounding epidermal cells. In cases of severe chronic rubbing or inflammation, the pigment can drop through the basement membrane into the dermis, where it is engulfed by macrophages (forming melanophages), resulting in deeply entrenched pigmentation.4 This process is further accelerated by ultraviolet (UV) radiation, which acts as a potent trigger for melanogenesis, compounding both genetic and inflammatory pigmentation.5

The Magnifying Effect of Structural Shadows

Even when melanin and vascular permeability are perfectly controlled, dark circles may persist due to the fundamental anatomical structure of the face. Structural dark circles are an optical illusion, dictated by the topographic thickness of the skin and the underlying skeletal framework.3

The primary biological constraint of the eye area is the extreme thinness of the skin. Topographic studies utilizing full-thickness punch biopsies have confirmed that the upper medial eyelid and infraorbital skin possess the thinnest dermis on the entire human body, measuring a mere 758.9 µm.3 Ultrasound imaging further corroborates that individuals with severe dark circles possess statistically significantly thinner under-eye skin compared to unaffected individuals.3

This extreme thinness acts like a translucent windowpane. It offers absolutely no physical camouflage for the highly vascularized orbicularis oculi muscle lying directly beneath, nor does it conceal the pooling of blood or the deposition of hemosiderin.4 As the skin ages, the chronological depletion of collagen and elastin fibers further thins this dermal matrix.14 Simultaneously, the orbital septum—a fibrous membrane holding periorbital fat in place—weakens. This allows internal orbital fat to herniate outward, creating "eye bags," while the loss of subcutaneous fat in the mid-face creates a hollow depression known as the tear trough.4 The physical protrusion of fat casts a deep shadow over the hollowed tear trough, creating a darkness that no topical brightener can erase.5

Chapter 4: The K-Beauty Scientific Renaissance: Next-Generation Clinical Solutions

Understanding the deep biology of your skin leads to a critical realization: a generic, one-size-fits-all eye cream is scientifically inadequate. To treat a desperate skin state, we must look to the vanguard of dermatological research. The Korean aesthetic and skincare industry has spearheaded a scientific renaissance, developing bioactive ingredients and advanced delivery systems that precisely target the distinct mechanisms of vascular permeability, melanogenesis, and dermal thinning.15

Targeting Vascular Permeability and Hemosiderin

To combat blood pooling and the leakage of red blood cells, formulations must focus on strengthening capillary walls, improving microcirculation, and acting upon blood coagulation pathways.

• Vitamin K Oxide (Phytonadione Epoxide): While traditional brightening agents fail on iron-rich hemosiderin stains, Vitamin K is uniquely capable of addressing vascular dark circles. It supports the proteins involved in blood clotting and vascular repair, strengthening capillary walls and reducing their visibility through thin skin.10 K-Beauty formulations utilize Vitamin K Oxide, a highly stable, oxidized derivative that provides superior efficacy in clearing pooled blood and redness while bypassing the irritation risks associated with pure Vitamin K1.10

• Venotonic Botanical Extracts: Advanced formulations increasingly rely on venotonic (vein-strengthening) plant extracts. For example, clinical studies demonstrate that Salix alba (willow) bark extract alleviates endothelial permeability, protects vascular integrity, and improves skin microcirculation, effectively treating the root cause of vascular dark circles.20

• Caffeine: Acting as a potent vasoconstrictor, caffeine immediately targets edema and puffiness. By temporarily constricting the dilated blood vessels beneath the skin, it forces stagnant blood back into systemic circulation, rapidly minimizing the bluish-purple hue and reducing the physical diameter of the leaky capillaries.21

Targeting Tyrosinase and Melanin Overdrive

Reversing melanin-induced shadowing requires molecules that interrupt the tyrosinase pathway and halt the transfer of pigment, without triggering further inflammatory hyperpigmentation.

• Tranexamic Acid (TXA): Originally an anti-fibrinolytic medication, topical TXA has revolutionized hyperpigmentation treatment. It functions by competitively binding to the tyrosinase enzyme, completely blocking melanin synthesis.5 Furthermore, it acts on the plasminogen pathway, severing the inflammatory communication between keratinocytes and melanocytes triggered by UV exposure or friction.25 Clinical trials evaluating K-Beauty serums combining TXA with Niacinamide and Vitamin C have shown statistically significant reductions in periorbital dark spots and overall melanin index within 8 weeks.26

• Niacinamide and Licorice Root: Niacinamide (Vitamin B3) excels by preventing the transfer of melanin-filled melanosomes to the surrounding epidermal cells.14 Simultaneously, Licorice Root Extract disperses existing excess melanin, providing an even, balanced finish while soothing the skin.28

Targeting Structural Shadows and Dermal Thinning

To address the sheer translucency of the eyelid skin, treatments must stimulate dermal fibroblasts to synthesize new collagen, thereby increasing the physical density and opacity of the tissue.

• PDRN (Polydeoxyribonucleotide): A major breakthrough in Korean aesthetic dermatology, PDRN consists of DNA fragments traditionally extracted from salmon sperm, and now sustainably sourced from microalgae (BluePDRN).29 PDRN operates via an adenosine A2A receptor mechanism to trigger profound tissue regeneration, promote angiogenesis (new blood vessel formation), and accelerate collagen accumulation.29 Used topically and via clinical microneedling, PDRN thickens the dermis, diminishes vascular shadows, and significantly enhances elasticity without adding artificial volume.31

• Stabilized Retinoids (Retinal and Bakuchiol): Vitamin A derivatives are the gold standard for dermal thickening. They stimulate type I collagen production and reorganize the extracellular matrix, physically thickening the dermis to hide underlying vascular networks.6 Due to the high irritation potential of traditional retinol around the eyes, K-Beauty labs (such as Amorepacific's IOPE) have pioneered stabilization technologies, utilizing double-conjugated, encapsulated retinol or retinaldehyde (retinal) to deliver the active molecule slowly and safely.33 Alternatively, Bakuchiol provides a plant-based option that mimics retinol's collagen-stimulating pathways without any associated irritation, making it perfect for sensitive, compromised skin.14

• Exosomes: Representing the absolute cutting edge of biotechnology, exosomes are nano-sized extracellular vesicles that act as cellular messengers.36 They deliver growth factors directly into senescent (aging) cells, modulating inflammation and stimulating matrix synthesis. Exosome-based eye creams have demonstrated exceptional efficacy in global periorbital rejuvenation, drastically reducing pigmentation and structural wrinkles in clinical trials.37

Biological Target	Advanced K-Beauty Ingredient	Mechanism of Action
Vascular / Hemosiderin	Vitamin K Oxide, Salix alba Extract	Enhances blood coagulation proteins, seals leaky capillaries, and clears iron-rich pooling.17
Vasodilation / Edema	Caffeine	Vasoconstriction of dilated vessels; rapidly reduces fluid buildup and blue hues.23
Melanin Synthesis	Tranexamic Acid (TXA)	Competitively binds tyrosinase and blocks inflammatory plasminogen pathways.24
Melanin Transfer	Niacinamide (Vit B3)	Blocks melanosome transfer to the epidermis; strengthens the lipid barrier.14
Dermal Thinning	Retinaldehyde, Bakuchiol	Stimulates fibroblast activity to synthesize Type I collagen, thickening the skin matrix.14
Tissue Regeneration	PDRN, Exosomes	Activates cellular repair via DNA fragments and cell-to-cell signaling vesicles.29

Chapter 5: Your Actionable Roadmap: Product Selection, Solutions, and Habits

Having decoded the intricate biology of the periorbital area, you are now equipped to take control of your skin. If your current state feels desperate, the key to recovery lies in meticulous consistency and matching the right clinical ingredients to your specific biological deficit. Below is a comprehensive, actionable roadmap designed to seamlessly integrate into your daily life.

Step 1: Diagnose Your Dark Circle Type

Before purchasing any product, perform a simple diagnostic test at home. Gently press a finger against your dark circle and pull the skin slightly downward and taut.

• If the darkness disappears or turns white: The issue is primarily vascular. Blood is pooling in the capillaries, and pressing forces the blood away temporarily.

• If the darkness moves with the skin and remains brown: The issue is pigmented. The melanin is fixed within the epidermal or dermal layers.

• If a shadow remains only in the hollow of your under-eye: The issue is structural, caused by volume loss and thinning skin casting a shadow.4

Step 2: Select the Right Topical Interventions

Based on your diagnosis, select targeted K-Beauty formulations. Avoid layering too many heavy creams, which can cause milia; instead, focus on potent, lightweight serums and encapsulated creams.39

• For Vascular & Puffy Eyes: Seek out lightweight gel-creams containing Caffeine and Vitamin K Oxide. Apply these primarily in the morning to constrict vessels and clear nocturnal fluid retention. Serums incorporating venotonic extracts like willow bark or green tea will provide sustained vascular support throughout the day.11

• For Pigmented & Sun-Damaged Eyes: Prioritize formulations featuring Tranexamic Acid (TXA), Niacinamide, and Vitamin C. These should be applied consistently day and night to persistently block tyrosinase activity. Consider K-Beauty eye patches infused with Licorice Root or Glutathione for a concentrated, 15-minute brightening boost a few times a week.41

• For Thin, Crepey, & Structural Shadows: You must incorporate collagen-stimulating ingredients. Introduce an eye cream containing encapsulated Retinal or Bakuchiol strictly into your nighttime routine.14 If your skin is highly compromised, seek out PDRN (often labeled as Salmon DNA or microalgal extracts) to rebuild the dermal density without irritation.29

Step 3: Implement Strategic Lifestyle Habits

Skincare cannot outwork detrimental physiological habits. To create the optimal environment for cellular repair, integrate these lifestyle adjustments:

• Elevate Your Sleep: Sleep with your head slightly elevated using an extra pillow. This utilizes gravity to prevent interstitial fluid and deoxygenated blood from pooling in the infraorbital region overnight, drastically reducing morning vascular puffiness.39 Ensure 7 to 9 hours of quality sleep to support systemic cell regeneration.11

• Thermal Regulation Therapy: Keep your K-Beauty hydrogel eye patches or a dedicated eye roller in the refrigerator.39 Applying a cold compress immediately initiates vasoconstriction, shrinking dilated blood vessels and rapidly reducing both swelling and the visible blue/purple hue of vascular circles.11

• Aggressive Allergy Management: If you suffer from seasonal allergies, asthma, or atopic dermatitis, systemic inflammation is likely driving your pigmented dark circles (PIH). Treat the underlying allergies with antihistamines and consciously avoid rubbing your eyes, as mechanical friction is a primary trigger for melanocyte overdrive and capillary damage.12

• Non-Negotiable UV Protection: Melanin production is directly accelerated by UV exposure. Apply a gentle, mineral-based broad-spectrum sunscreen all the way up to the lash line every single day.21 Without SPF, tyrosinase inhibitors like Tranexamic Acid are rendered useless.

Step 4: Consider At-Home Devices and Clinical Aesthetics

If your skin requires advanced intervention, consider supplementing your topical routine with technology.

• Microcurrent & LED Therapy: At-home microcurrent devices stimulate the orbicularis oculi muscle, promoting lymphatic drainage and lifting structural contours.46 LED light therapy (red/near-infrared) penetrates the dermis to enhance cellular ATP production, supporting the natural healing of thinned skin without any downtime.47

• Professional Treatments: For structural dark circles caused by severe fat pad herniation or deep tear troughs, acknowledge the limitations of topicals. Consult a board-certified dermatologist regarding clinical PDRN microneedling, hyaluronic acid fillers, or laser therapy (such as Q-switched Nd:YAG) to directly target dermal melanocytosis or deep vascular networks.4

Healing a desperate skin state is not an overnight process; it requires the same patience and precision as any biological repair. By correctly identifying your dark circle type, leveraging the cutting-edge science of K-Beauty ingredients, and committing to supportive physiological habits, you can restore the structural integrity and bright, youthful luminosity of your eyes. Be patient, stay consistent, and trust the science.

Works cited

1. Physiological and lifestyle factors contributing to risk and severity of peri-orbital dark circles in the Brazilian population - PMC, accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC4560538/

2. Best Eye Bag Treatments: Type-Based Solutions for Dark Circles and Under-Eye Fat, accessed February 23, 2026, https://jivaka.kr/blogs/blog/best-eye-bag-treatments-type-based-solutions-for-dark-circles-and-under-eye-fat

3. Identification Of Three Key Factors Contributing To The Aetiology Of ..., accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC6927230/

4. Electrical stimulation of the lower eyelid orbicularis oculi muscle ..., accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC11016813/

5. Periorbital Hyperpigmentation: A Comprehensive Review - PMC - NIH, accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC4756872/

6. Infraorbital Dark Circles: A Review of the Pathogenesis, Evaluation and Treatment - PMC, accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC4924417/

7. Hemosiderin Staining: What Causes this Common Discoloration on Your Legs? - WebMD, accessed February 23, 2026, https://www.webmd.com/skin-problems-and-treatments/what-is-hemosiderin-staining

8. Hemosiderin staining product of trauma or venous insufficiency - UCLA Health, accessed February 23, 2026, https://www.uclahealth.org/news/article/hemosiderin-staining-product-trauma-or-venous-insufficiency

9. More Than a Cover-Up: Options for Patients with Periorbital Hyperpigmentation - PCCA, accessed February 23, 2026, https://www.pccarx.com/Blog/more-than-a-cover-up-options-for-patients-with-periorbital-hyperpigmentation

10. Role of Vitamin K in Personal Care Chemistry and Skincare Formulations - Elchemy, accessed February 23, 2026, https://elchemy.com/blogs/personal-care/role-of-vitamin-k-in-personal-care-chemistry-and-skincare-formulations

11. What Causes Dark Circles & How to Reduce Them: Best Diet Tips | Max Hospital, accessed February 23, 2026, https://www.maxhealthcare.in/blogs/how-to-reduce-dark-circle

12. Dark Circles Under The Eyes: Causes & Treatment - Cleveland Clinic, accessed February 23, 2026, https://my.clevelandclinic.org/health/symptoms/23128-dark-circles-under-eyes

13. What causes dark circles under the eyes? - PubMed, accessed February 23, 2026, https://pubmed.ncbi.nlm.nih.gov/17760701/

14. How to Get Rid of Dark Circles: The Ultimate Dermatologist-Approved Guide, accessed February 23, 2026, https://drsambunting.com/en-us/blogs/sam-bunting/dark-circles-the-ultimate-dermatologist-guide

15. Korean Eye Care Products | K-Beauty Eye Creams - Peach & Lily, accessed February 23, 2026, https://www.peachandlily.com/collections/eye-treatments

16. 2026 K-Beauty Trends: Must-Know Skincare and Makeup, accessed February 23, 2026, https://www.shoppalacebeauty.com/blogs/news/2026-k-beauty-trends-must-know-skincare-and-makeup

17. Evaluation of the clinical efficacy and safety of an eye counter pad containing caffeine and vitamin K in emulsified Emu oil base - PMC, accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC4300604/

18. How does Vitamin K have skin benefits? - Typology, accessed February 23, 2026, https://us.typology.com/library/what-are-the-benefits-of-vitamin-k-for-the-skin

19. Call for data on phytonadione epoxide used in cosmetic products, accessed February 23, 2026, https://single-market-economy.ec.europa.eu/consultations/call-data-phytonadione-epoxide-used-cosmetic-products_en

20. The effect of Salix alba L. bark extract on dark circles in vitro and in vivo - PubMed, accessed February 23, 2026, https://pubmed.ncbi.nlm.nih.gov/37235713/

21. How to Get Rid of Dark Circles: The Ultimate Dermatologist-Approved Guide, accessed February 23, 2026, https://drsambunting.com/blogs/sam-bunting/dark-circles-the-ultimate-dermatologist-guide

22. A review of the efficacy of popular eye cream ingredients - PMC, accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC11175953/

23. Korean Dark Circle Treatments: What Actually Works? - Seoul Cosmetic Surgery, accessed February 23, 2026, https://seoulcosmeticsurgery.com/korean-dark-circle-treatments/

24. Full article: Efficacy and safety of injectable sodium hyaluronate with vitamin C, tranexamic acid, and glutathione for pigmented dark circles - Taylor & Francis, accessed February 23, 2026, https://www.tandfonline.com/doi/full/10.1080/09546634.2025.2574306

25. (PDF) Mechanism of Action of Topical Tranexamic Acid in the Treatment of Melasma and Sun-Induced Skin Hyperpigmentation - ResearchGate, accessed February 23, 2026, https://www.researchgate.net/publication/364394383_Mechanism_of_Action_of_Topical_Tranexamic_Acid_in_the_Treatment_of_Melasma_and_Sun-Induced_Skin_Hyperpigmentation

26. Pilot Clinical Safety and Efficacy Evaluation of a Topical 3% Tranexamic Acid Cream and Serum Protocol for Managing Facial Hyperpigmentation in Caucasian Patients - MDPI, accessed February 23, 2026, https://www.mdpi.com/2079-9284/11/5/168

27. Tranexamic Acid for the Treatment of Hyperpigmentation and Telangiectatic Disorders Other Than Melasma: An Update - PMC, accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC11439988/

28. How to Treat the Look of Dark Circles With the Right Products - Venofye, accessed February 23, 2026, https://venofye.com/how-to-treat-the-look-of-dark-circles-with-the-right-products/

29. PDRN: What Is It, Its Skincare Benefits And More | Harper's Bazaar Singapore, accessed February 23, 2026, https://www.harpersbazaar.com.sg/beauty/skincare/pdrn-things-to-know

30. Amorepacific Research Confirms Potential of Microalgal-Derived ..., accessed February 23, 2026, https://stories.amorepacific.com/en/amorepacific-research-confirms-potential-of-microalgal-derived-pdrns-in-skin-regeneration-and-wound-healing/

31. PDRN Treatment for Under Eyes - Derma Puritys, accessed February 23, 2026, https://dermapuritys.com/blog/pdrn-treatment-for-under-eyes

32. What Is PDRN Treatment for Eyes? - Dermax Aesthetics, accessed February 23, 2026, https://www.dermaxmed.com/what-is-pdrn-treatment-for-eyes.html

33. Efficacy and Tolerability of a Retinoid Eye Cream for Fine to Moderate Wrinkles of the Periorbital Region - PubMed, accessed February 23, 2026, https://pubmed.ncbi.nlm.nih.gov/36074511/

34. The Science of Anti-Aging: Exploring IOPE's Innovative Take on Retinol - Soko Glam, accessed February 23, 2026, https://sokoglam.com/blogs/theklog/the-science-of-anti-aging-exploring-iopes-award-winning-retinol-expert-0-1-and-the-anticipated-retinol-super-bounce-serum

35. The Best Korean Eye Creams – Tried, Tested, and Truly Worth It - SKINSIDER, accessed February 23, 2026, https://skinsider.co.uk/blog/the-best-korean-eye-creams-tried-tested-and-truly-worth-it/

36. Exosomes in 2026: hype and potential - CellGS, accessed February 23, 2026, https://www.cellgs.com/blog/exosomes-in-2026-hype-and-potential.html

37. 2026 Clinical Skincare Trends: How Biotech, Exosomes, and Barrier-First Formulas Are Redefining Professional Beauty - adoreyes, accessed February 23, 2026, https://adoreyes.com/blogs/news/2026-clinical-skincare-trends-how-biotech-exosomes-and-barrier-first-formulas-are-redefining-professional-beauty

38. Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sulfate (LMW‐HS) and a blend of naturally derived extracts - PMC, accessed February 23, 2026, https://pmc.ncbi.nlm.nih.gov/articles/PMC6850077/

39. Korean eyes Dark Circles, Puffiness & Fine Lines Products – Lakinza K-beauty, accessed February 23, 2026, https://www.lakinza.ca/blogs/news/korean-skincare-for-dark-circles-puffy-eyes-and-fine-lines

40. Dark Circle Ingredients: A Comprehensive Guide for 2026 - Rixin Cosmetics, accessed February 23, 2026, https://rixincosmetics.com/blog/dark-circle-ingredients/

41. Best Eye Cream for Dark Circles – Top Korean Solutions for Under-Eye Shadows - Skinsider, accessed February 23, 2026, https://skinsider.co.uk/blog/best-eye-cream-for-dark-circles-top-korean-solutions-for-undereye-shadows/

42. Puffiness, Dark Circles, and Wrinkles Are No Match for These Under-Eye Masks - ELLE, accessed February 23, 2026, https://www.elle.com/beauty/makeup-skin-care/g30254/best-under-eye-mask-patches/

43. Dark circles under eyes In-depth - Mayo Clinic, accessed February 23, 2026, https://www.mayoclinic.org/symptoms/dark-circles-under-eyes/in-depth/sym-20050624?p=1

44. Dark circles can arise from health issues, lifestyle or genetics | UCLA Health, accessed February 23, 2026, https://www.uclahealth.org/news/article/dark-circles-can-arise-health-issues-lifestyle-or-genetics

45. Dark circles under eyes Causes - Mayo Clinic, accessed February 23, 2026, https://www.mayoclinic.org/symptoms/dark-circles-under-eyes/basics/causes/sym-20050624?p=1

46. Microcurrent Eye Treatments: A DIY Approach to Youthful Skin - EVENSKYN, accessed February 23, 2026, https://www.evenskyn.com/blogs/skin-beautyarticles/microcurrent-eye-treatments-a-diy-approach-to-youthful-skin

47. The Dynamic Combination of LED Light Therapy and Microcurrent - services in Hudson, NH - Anika Skincare & Makeup, accessed February 23, 2026, https://www.anikabeauty.com/blogs/premium-skincare/the-dynamic-combination-of-led-light-therapy-and-microcurrent/

48. LED Light Therapy vs. Microcurrent: Key Differences and Benefits, accessed February 23, 2026, https://ledesthetics.com/blogs/technology/led-light-therapy-vs-microcurrent-key-differences-and-benefits